Stanford University



Owen, L M, Adhikari, A S, Patel, M, Grimmer, P, Leijnse, N, Kim, MC, Notbohm, J, Franck, C, Dunn, AR. A cytoskeletal clutch mediates cellular force transmission in a soft, 3D extracellular matrix. June 2017. doi: 10.1091/mbc.E17-02-0102 link

Mekhdjian, Armen H, Kai, FuiBoon, Rubashkin, Matthew G, Prahl, Louis S, Przybyla, Laralynne M, McGregor, Alexandra L ,Bell, Emily S, Barnes, J Matthew, DuFort, Christopher C, Ou, Guanqing, Chang, Alice C, Cassereau, Luke, Tan, Steven J, Pickup, Michael W, Lakins, Jonathan N, Ye, Xin, Davidson, Michael W, Lammerding, Jan, Odde, David J, Dunn, Alexander R, Weaver, Valerie M. Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix. March 2017. MBoC. doi: 10.1091/mbc.E16-09-0654 link


Price AJ, Huang EY, Sebastiano V, Dunn AR. A semi-interpenetrating network of polyacrylamide and recombinant basement membrane allows pluripotent cell culture in a soft, ligand-rich microenvironment. Biomaterials. 2016;121:179-192. doi:10.1016/j.biomaterials.2016.12.005 link

Vinay N. SuryaEleftheria MichalakiEva Y. HuangGerald G. FullerAlexander R. Dunn. Sphingosine 1-phosphate receptor 1 regulates the directional migration of lymphatic endothelial cells in response to fluid shear stress. Journal of royal society of interface. 2016. Volume 13, issue 125. link

Chang AC, Mekhdjian AH, Morimatsu M, Denisin AK, Pruitt BL, Dunn AR. Single Molecule Force Measurements in Living Cells Reveal a Minimally Tensioned Integrin State. ACS Nano. October 2016. doi:10.1021/acsnano.6b03314. Link

Lockhead D, Schwarz EM, O'Hagan R, Bellotti S, Krieg M, Barr MM, Dunn AR, Sternberg PW, Goodman MB. The tubulin repertoire of C. elegans sensory neurons and its context-dependent role in process outgrowth. Mol Biol Cell. 2016 Sep 21. pii: mbc.E16-06-0473 Link

Sun Z, Tseng HY, Tan S, Senger F, Kurzawa L, Dedden D, Mizuno N, Wasik AA, Thery M, Dunn AR, Fässler R. Kank2 activates talin, reduces force transduction across integrins and induces central adhesion formation. Nat Cell Biol. 2016 Sep;18(9):941-53. Link

Dunn AR. How Hydra Eats. Biophys J. 2016 Apr 12;110(7):1467-8.Link

Nakayama KH, Surya VN, Gole M, Walker TW, Yang W, Lai ES, Ostrowski MA, Fuller GG, Dunn AR, Huang NF. "Nanoscale Patterning of Extracellular Matrix Alters Endothelial Function under Shear Stress." Nano Letters. 2016 January 13. Link


Ostrowski, M. A., Huang, E. Y., Surya, V. N., Poplawski, C., Barakat, J. M., Lin, G. L., Dunn, A. R. "Multiplexed Fluid Flow Device to Study Cellular Response to Tunable Shear Stress Gradients." Annals of Biomedical Engineering. 2015 November 20. Link

Chai, J., Hamilton, A., Krieg, M., Buckley, C., Riedel-Kruse, I., Dunn, A. R. "A Force Balance Can Explain Local and Global Cell Movements During Early Zebrafish Development." Biophysical Journal. 2015 July 21. Link

Sim, J. Y., Moeller, J., Hart, K. C., Ramallo, D., Vogel, V., Dunn, A. R., Pruitt, B. L. "Spatial distribution of cell-cell and cell-ECM adhesions regulates force balance while main-taining E-cadherin molecular tension in cell pairs." Molecular Biology of the Cell, 26(13), 2456–65. 2015 July 1. Link

Morimatsu, M., Mekhdjian, A. H., Chang, A. C.-C., Tan, S. J., & Dunn, A. R. "Visualizing the interior architecture of focal adhesions with high-resolution traction maps." Nano Letters. 2015 March. Link

Price, A., Dunn, AR. "Energetics and Forces in Living Cells." Physics Today. 2015 February. Link


Pruitt, B. L., Dunn, AR, Weis, W. I., Nelson, W. J. "Mechano-Transduction: From Molecules to Tissues." PloS Biology. 2014 November 18. Link

Buckley, Craig D., Tan, Jiongyi, Anderson, Karen L., Hanein, Dorit, Volkmann, Niels, Weis, William I., Nelson, W. James,Dunn AR. "The minimal cadherin-catenin complex bind to actin filaments under force." Science. 2014 October 31. Link

Kreig M, Dunn AR, Goodman MB. "Mechanical Control of the sense of touch by ß-spectrin." Nature Cell Biology. 2014 February 23. Link

Ostrowski MA, Huang NF, Walker TW, Verwijlen T, Poplawski C, Khoo AS, Cooke JP, Fuller GG, Dunn AR. "Microvascular endothelial cells migrate upstream and align against the shear stress field created by impinging flow." Biophysical Journal. 2014 January 21. Link


Morimatsu M, Mekhdjian AH, Adhikari AS, Dunn AR. "Molecular tension sensors report forces generated by single integrin molecules in living cells." Nano Letters. 2013 July 16. Link

Borghi N, Sorokina M, Shcherbakova OG, Weis WI, Pruitt BL, Nelson WJ, Dunn AR. "E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch." PNAS. 2012 July 16. Link


Adhikari AS, Glassey E, Dunn AR. "Conformational Dynamics Accompanying the Proteolytic Degradation of Trimeric Collagen I by Collagenases." JACS. 2012 June 21. Link

Adhikari AS, Chai J, Dunn AR. "Multiplexed Single-molecule Force Proteolysis Measurements Using Magnetic Tweezers." JoVE. 2012. Link


Adhikari AS, Mekhdjian AH, Dunn AR. "Strain Tunes Proteolytic Degradation and Diffusive Transport in Fibrin Networks." Biomacromolecules. 2011 Dec 20. Link

Adhikari A, Chai J, Dunn AR. "Mechanical Load Induced a 100-fold increase in the Rate of Collagen Proteolysis by MMP-1." JACS. 2011 Jan 19. Link


Chuan P, Spudich JA, Dunn AR. "Robust Mechanosensing and Tension Generation by Myosin VI." J Mol Biol. 2010 Oct 21. Link

Sung J, Sivaramakrishnan S, Dunn AR, Spudich JA. "Single-molecule dual-beam optical trap analysis of protein structure and function." Methods Enzymol. 2010;475:321-75. Link

Dunn AR, Chuan P, Bryant Z, Spudich JA. "Contribution of the myosin VI tail domain to processive stepping and intramolecular tension sensing." PNAS. 2010 Apr 12. Link


Pierobon P, Achouri S, Courty S, Dunn AR, Spudich JA, Dahan M, Cappello G. "Velocity, processivity, and individual steps of single myosin V molecules in live cells." Biophys. J. 2009. 96(10):4268 Link


Dunn AR; Spudich, J. A. "Single-molecule gold-nanoparticle tracking with high temporal and spatial resolution and without an applied load." Laboratory Manual for Single Molecule Studies, Cold Spring Harbor Laboratory Press, Woodbury, NY; 2007 Link

Tang, S., Liao, J.-C., Dunn, A. R., Altman, R. B., Spudich, J. A. & Schmidt, J. P. "Predicting allosteric communication in myosin via a pathway of conserved residues." J. Mol. Biol. 373, 1361-1373 (2007). Link

Dunn, A. R. & Spudich, J. A. "Dynamics of the unbound head during myosin V processive translocation." Nat. Struct. Mol. Biol. 14,246-248 (2007). Link


Rock, R. S., Ramamurthy, B., Dunn, A. R., Beccafico, S., Rami, B. R., Morris, C., Spink, B. J., Franzini-Armstrong, C., Spudich, J. A. & Sweeney, H. L. "A flexible domain is essential for the large step size and processivity of myosin VI." Mol. Cell 17, 603-609 (2005). Link

Contakes, S. M., Juda, G. A., Langley, D. B., Halpern-Manners, N. W., Duff, A. P.,Dunn, A. R., Gray, H. B., Dooley, D. M., Guss, J. M. & Freeman, H. C. "Reversible inhibition of copper amine oxidase activity by channel-blocking ruthenium(II) and rhenium(I) molecular wires." Proc. Natl. Acad. Sci. U.S.A. 102, 13451-12456 (2005). Link

Belliston-Bittner, W., Dunn, A. R., Nguyen, Y. H. L., Stuehr, D. J., Winkler, J. R. & Gray, H. B. "Picosecond photoreduction of inducible nitric oxide synthase by rhenium(I)-diimine wires." J. Am. Chem. Soc. 127, 15907-15915 (2005). Link

Dunn, A. R., Belliston-Bittner, W., Winkler, J. R., Getzoff, E. D., Stuehr, D. J. & Gray, H. B. "Luminescent ruthenium(II)- and rhenium(I)-diimine wires bind nitric oxide synthase." J. Am. Chem. Soc. 127, 5169-5173 (2005). Link


Rucker, V. C., Dunn, A. R., Sharma, S., Dervan, P. B. & Gray, H. B. "Mechanism of sequence-specific fluorescent detection of DNA by N-methyl-imidazole, N-methyl-pyrrole, and ß-alanine linked polyamides." J. Phys. Chem. B 108, 7490-7494 (2004). Link

Hays, A.-M. A., Dunn, A. R., Chiu, R., Gray, H. B., Stout, C. D., & Goodin, D. B. "Conformational states of cytochrome P450cam revealed by trapping of synthetic molecular wires." J. Mol. Biol. 2, 455-469 (2004). Link


Dunn, A. R., Dmochowski, I. J., Winkler, J. R. & Gray, H. B. "Nanosecond photoreduction of cytochrome P450cam by channel-specific electron tunneling Ru-diimine wires." J. Am. Chem. Soc. 41, 12450-12456 (2003). Link


Dunn, A. R., Hays, A.-M. A., Goodin, D. B., Stout, C. D., Chiu, R., Winkler, J. R. & Gray, H. B. "Fluorescent probes for cytochrome P450 structural characterization and inhibitor screening." J. Am. Chem. Soc. 124, 10254-10255 (2002). Link

Dmochowski, I. J., Dunn, A. R., Wilker, J. J., Crane, B. R., Green, M., Dawson, J. H., Sligar, S. G., Winkler, J. R. & Gray, H. B. "Ruthenium probes of P450 structure and mechanism." Meth. Enzymol. 357, 120-133 (2002). Link


Dunn, A. R., Dmochowski, I. J., Bilwes, A. M., Gray, H. B. & Crane B. R. "Probing the open state of cytochrome P450cam with ruthenium-linker substrates." Proc. Natl. Acad. Sci. U.S.A. 98, 12420-12425 (2001). Link


Weck, M., Dunn, A. R., Matsumoto, K., Coates, G. W., Lobkovsky, E. B. & Grubbs R. H. "Influence of perfluoroarene-arene interactions on the phase behavior of liquid crystalline and polymeric materials." Angew. Chem. Int. Ed. Engl. 38, 2741-2745 (1999). Link


Coates, G. W., Dunn, A. R., Henling, L. M., Ziller, J. W., Lobkovsky, E. B. & Grubbs, R. H. "Phenyl-perfluorophenyl stacking interactions: Topochemical[2+2] photodimerization and photopolymerization of olefinic compounds." J. Am. Chem. Soc. 120, 3641-3649 (1998). Link

Bloom, C. R., Wu, N., Dunn, A., Kaarsholm, N. C. & Dunn, M. F. "Comparison of the allosteric properties of the Co(II)- and Zn(II)-substituted insulin hexamers." Biochemistry 37, 10937-10944 (1998). Link


Coates, G. W., Dunn, A. R., Henling, L. M., Dougherty, D. A. & Grubbs, R. H. "Phenyl-perfluorophenyl stacking interactions: A new strategy for supermolecule construction." Angew. Chem. Int. Ed. Engl. 36, 248-251 (1997). Link