Stanford University

Publications

2017

Huang DL, Bax NA, Buckley CD, Weis WI, Dunn AR. Vinculin forms a directionally asymmetric catch bond with F-actin. Science. 2017;357(6352):703-706.

Owen, L M, Adhikari, A S, Patel, M, Grimmer, P, Leijnse, N, Kim, MC, Notbohm, J, Franck, C, Dunn, AR. A cytoskeletal clutch mediates cellular force transmission in a soft, 3D extracellular matrix. MBoC. June 2017. doi: 10.1091/mbc.E17-02-0102

Mekhdjian, Armen H, Kai, FuiBoon, Rubashkin, Matthew G, Prahl, Louis S, Przybyla, Laralynne M, McGregor, Alexandra L ,Bell, Emily S, Barnes, J Matthew, DuFort, Christopher C, Ou, Guanqing, Chang, Alice C, Cassereau, Luke, Tan, Steven J, Pickup, Michael W, Lakins, Jonathan N, Ye, Xin, Davidson, Michael W, Lammerding, Jan, Odde, David J, Dunn, Alexander R, Weaver, Valerie M. Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix. MBoC. March 2017. doi: 10.1091/mbc.E16-09-0654

2016

Price AJ, Huang EY, Sebastiano V, Dunn AR. A semi-interpenetrating network of polyacrylamide and recombinant basement membrane allows pluripotent cell culture in a soft, ligand-rich microenvironment.Biomaterials. 2016;121:179-192. doi:10.1016/j.biomaterials.2016.12.005

Vinay N. Surya, Eleftheria Michalaki, Eva Y. Huang, Gerald G. Fuller, Alexander R. Dunn. Sphingosine 1-phosphate receptor 1 regulates the directional migration of lymphatic endothelial cells in response to fluid shear stress. Journal of Royal Society of Interface. 2016. Volume 13, Issue 125.

Chang AC, Mekhdjian AH, Morimatsu M, Denisin AK, Pruitt BL, Dunn AR. Single Molecule Force Measurements in Living Cells Reveal a Minimally Tensioned Integrin State. ACS Nano. October 2016. doi:10.1021/acsnano.6b03314.

Lockhead D, Schwarz EM, O'Hagan R, Bellotti S, Krieg M, Barr MM, Dunn AR, Sternberg PW, Goodman MB. The tubulin repertoire of C. elegans sensory neurons and its context-dependent role in process outgrowth. Mol Biol Cell. 2016 Sep 21. pii: mbc.E16-06-0473

Sun Z, Tseng HY, Tan S, Senger F, Kurzawa L, Dedden D, Mizuno N, Wasik AA, Thery M, Dunn AR, Fässler R. Kank2 activates talin, reduces force transduction across integrins and induces central adhesion formation. Nat Cell Biol. 2016 Sep;18(9):941-53.

Dunn AR. How Hydra Eats. Biophys J. 2016 Apr 12;110(7):1467-8.

Nakayama KH, Surya VN, Gole M, Walker TW, Yang W, Lai ES, Ostrowski MA, Fuller GG, Dunn AR, Huang NF. Nanoscale Patterning of Extracellular Matrix Alters Endothelial Function under Shear Stress. Nano Letters. 2016 January 13.

2015

Ostrowski, M. A., Huang, E. Y., Surya, V. N., Poplawski, C., Barakat, J. M., Lin, G. L., Dunn, A. R. Multiplexed Fluid Flow Device to Study Cellular Response to Tunable Shear Stress Gradients. Annals of Biomedical Engineering. 2015 November 20.

Chai, J., Hamilton, A., Krieg, M., Buckley, C., Riedel-Kruse, I., Dunn, A. R. A Force Balance Can Explain Local and Global Cell Movements During Early Zebrafish Development. Biophysical Journal. 2015 July 21.

Sim, J. Y., Moeller, J., Hart, K. C., Ramallo, D., Vogel, V., Dunn, A. R., Pruitt, B. L. Spatial distribution of cell-cell and cell-ECM adhesions regulates force balance while main-taining E-cadherin molecular tension in cell pairs. Molecular Biology of the Cell, 26(13), 2456–65. 2015 July 1.

Morimatsu, M., Mekhdjian, A. H., Chang, A. C.-C., Tan, S. J., & Dunn, A. R. Visualizing the interior architecture of focal adhesions with high-resolution traction maps. Nano Letters. 2015 March.

Price, A., Dunn, AR. Energetics and Forces in Living Cells. Physics Today. 2015 February.

2014

Pruitt, B. L., Dunn, AR, Weis, W. I., Nelson, W. J. Mechano-Transduction: From Molecules to Tissues. PloS Biology. 2014 November 18.

Buckley, Craig D., Tan, Jiongyi, Anderson, Karen L., Hanein, Dorit, Volkmann, Niels, Weis, William I., Nelson, W. James,Dunn AR. The minimal cadherin-catenin complex bind to actin filaments under force. Science. 2014 October 31.

Kreig M, Dunn AR, Goodman MB. Mechanical Control of the sense of touch by ß-spectrin. Nature Cell Biology. 2014 February 23.

Ostrowski MA, Huang NF, Walker TW, Verwijlen T, Poplawski C, Khoo AS, Cooke JP, Fuller GG, Dunn AR. Microvascular endothelial cells migrate upstream and align against the shear stress field created by impinging flow. Biophysical Journal. 2014 January 21.

2013

Morimatsu M, Mekhdjian AH, Adhikari AS, Dunn AR. Molecular tension sensors report forces generated by single integrin molecules in living cells. Nano Letters. 2013 July 16.

Borghi N, Sorokina M, Shcherbakova OG, Weis WI, Pruitt BL, Nelson WJ, Dunn AR. E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch. PNAS. 2012 July 16.

2012

Adhikari AS, Glassey E, Dunn AR. Conformational Dynamics Accompanying the Proteolytic Degradation of Trimeric Collagen I by Collagenases. JACS. 2012 June 21.

Adhikari AS, Chai J,Dunn AR. Multiplexed Single-molecule Force Proteolysis Measurements Using Magnetic Tweezers. JoVE. 2012.

2011

Adhikari AS, Mekhdjian AH,Dunn AR. Strain Tunes Proteolytic Degradation and Diffusive Transport in Fibrin Networks. Biomacromolecules. 2011 Dec 20.

Adhikari A, Chai J,Dunn AR. Mechanical Load Induced a 100-fold increase in the Rate of Collagen Proteolysis by MMP-1. JACS. 2011 Jan 19.

2010

Chuan P, Spudich JA,DunnAR. Robust Mechanosensing and Tension Generation by Myosin VI. J Mol Biol. 2010 Oct 21.

Sung J, Sivaramakrishnan S,Dunn AR, Spudich JA. Single-molecule dual-beam optical trap analysis of protein structure and function. Methods Enzymol. 2010;475:321-75.

Dunn AR, Chuan P, Bryant Z, Spudich JA. Contribution of the myosin VI tail domain to processive stepping and intramolecular tension sensing. PNAS. 2010 Apr 12.

2009

Pierobon P, Achouri S, Courty S,Dunn AR, Spudich JA, Dahan M, Cappello G. Velocity, processivity, and individual steps of single myosin V molecules in live cells. Biophys. J. 2009. 96(10):4268

2007

Dunn AR; Spudich, J. A. Single-molecule gold-nanoparticle tracking with high temporal and spatial resolution and without an applied load. Laboratory Manual for Single Molecule Studies, Cold Spring Harbor Laboratory Press, Woodbury, NY; 2007

Tang, S., Liao, J.-C.,Dunn, A. R., Altman, R. B., Spudich, J. A. Schmidt, J. P. Predicting allosteric communication in myosin via a pathway of conserved residues. J. Mol. Biol. 373, 1361-1373 (2007).

Dunn, A. R. Spudich, J. A. Dynamics of the unbound head during myosin V processive translocation. Nat. Struct. Mol. Biol. 14,246-248 (2007).

2005

Rock, R. S., Ramamurthy, B.,Dunn, A. R., Beccafico, S., Rami, B. R., Morris, C., Spink, B. J., Franzini-Armstrong, C., Spudich, J. A. Sweeney, H. L. A flexible domain is essential for the large step size and processivity of myosin VI. Mol. Cell 17, 603-609 (2005).

Contakes, S. M., Juda, G. A., Langley, D. B., Halpern-Manners, N. W., Duff, A. P.,Dunn, A. R., Gray, H. B., Dooley, D. M., Guss, J. M. Freeman, H. C. Reversible inhibition of copper amine oxidase activity by channel-blocking ruthenium(II) and rhenium(I) molecular wires. Proc. Natl. Acad. Sci. U.S.A. 102, 13451-12456 (2005).

Belliston-Bittner, W.,Dunn, A. R., Nguyen, Y. H. L., Stuehr, D. J., Winkler, J. R. Gray, H. B. Picosecond photoreduction of inducible nitric oxide synthase by rhenium(I)-diimine wires. J. Am. Chem. Soc. 127, 15907-15915 (2005).

Dunn, A. R., Belliston-Bittner, W., Winkler, J. R., Getzoff, E. D., Stuehr, D. J. Gray, H. B. Luminescent ruthenium(II)- and rhenium(I)-diimine wires bind nitric oxide synthase. J. Am. Chem. Soc. 127, 5169-5173 (2005).

2004

Rucker, V. C.,Dunn, A. R., Sharma, S., Dervan, P. B. Gray, H. B. Mechanism of sequence-specific fluorescent detection of DNA by N-methyl-imidazole, N-methyl-pyrrole, and ß-alanine linked polyamides. J. Phys. Chem. B 108, 7490-7494 (2004).

Hays, A.-M. A.,Dunn, A. R., Chiu, R., Gray, H. B., Stout, C. D., Goodin, D. B. Conformational states of cytochrome P450cam revealed by trapping of synthetic molecular wires. J. Mol. Biol. 2, 455-469 (2004).

2003

Dunn, A. R., Dmochowski, I. J., Winkler, J. R. Gray, H. B. Nanosecond photoreduction of cytochrome P450cam by channel-specific electron tunneling Ru-diimine wires. J. Am. Chem. Soc. 41, 12450-12456 (2003).

2002

Dunn, A. R., Hays, A.-M. A., Goodin, D. B., Stout, C. D., Chiu, R., Winkler, J. R. Gray, H. B. Fluorescent probes for cytochrome P450 structural characterization and inhibitor screening. J. Am. Chem. Soc. 124, 10254-10255 (2002).

Dmochowski, I. J.,Dunn, A. R., Wilker, J. J., Crane, B. R., Green, M., Dawson, J. H., Sligar, S. G., Winkler, J. R. Gray, H. B. Ruthenium probes of P450 structure and mechanism. Meth. Enzymol. 357, 120-133 (2002).

2001

Dunn, A. R., Dmochowski, I. J., Bilwes, A. M., Gray, H. B. Crane B. R. Probing the open state of cytochrome P450cam with ruthenium-linker substrates. Proc. Natl. Acad. Sci. U.S.A. 98, 12420-12425 (2001).

2000

Weck, M.,Dunn, A. R., Matsumoto, K., Coates, G. W., Lobkovsky, E. B. Grubbs R. H. Influence of perfluoroarene-arene interactions on the phase behavior of liquid crystalline and polymeric materials. Angew. Chem. Int. Ed. Engl. 38, 2741-2745 (1999).

1998

Coates, G. W.,Dunn, A. R., Henling, L. M., Ziller, J. W., Lobkovsky, E. B. Grubbs, R. H. Phenyl-perfluorophenyl stacking interactions: Topochemical[2+2] photodimerization and photopolymerization of olefinic compounds. J. Am. Chem. Soc. 120, 3641-3649 (1998).

Bloom, C. R., Wu, N.,Dunn, A., Kaarsholm, N. C. Dunn, M. F. Comparison of the allosteric properties of the Co(II)- and Zn(II)-substituted insulin hexamers. Biochemistry 37, 10937-10944 (1998).

1997

Coates, G. W.,Dunn, A. R., Henling, L. M., Dougherty, D. A. Grubbs, R. H. Phenyl-perfluorophenyl stacking interactions: A new strategy for supermolecule construction. Angew. Chem. Int. Ed. Engl. 36, 248-251 (1997).